After graduating from Architecture in Florence, Branzi founds Archizoom, a radical group known for its visionary projects (No-Stop City, 1966) and anti-design for Poltronova (the Superondasofa, 1967 and the Mies armchair, 1970).
In 1975 he cofounds the CDM studio for design research. Branzi opens a studio in 1982 to design products and conduct research for companies like Memphis and Vitra.
A theoretician of design, exhibition curator, author, and director of the magazine Modo, Branzi founds the Domus Academy in Milan and then becomes a full professor at the Milan Polytechnic.
These activities lead to awarding him a Golden Compass Award for his career and an Honorary Degree from Rome’s La Sapienza University.